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People who have difficulty dealing with stress, anxiety or sleeplessness may overuse or become dependent on sedatives.Some heroin users may take them either to supplement their drug or to substitute for it.In spite of the fact that each sedative acts in its own way, they produce beneficial relaxing effect by increasing GABA activity.At higher doses it may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes.This means that first-generation antihistamines are more likely to cause side effects such as sedation, dry mouth, dizziness, low blood pressure, and a rapid heart-beat.

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Although sedatives do not relieve pain in themselves, they can be a useful adjunct to analgesics in preparing patients for surgery, and are commonly given to patients before they are anaesthetized, or before other highly uncomfortable and invasive procedures like cardiac catheterization, colonoscopy or MRI.Both physical and psychological dependence can be treated with therapy.Many sedatives can be misused, but barbiturates and benzodiazepines are responsible for most of the problems with sedative use due to their widespread recreational or non-medical use.They are central nervous depressants and interact with brain activity causing its deceleration.Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA), which are brain chemicals performing communication between brain cells.

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